Glioblastoma multiforme (GBM), or grade IV astrocytoma, is the most typical and lethal main malignant brain tumor in humans. Regardless of surgical resection and remedy with ionizing radiation (IR) and temozolamide, the median survival for GBM patients is approximately 1 year . Virtually all patients suffer tumor recurrence in spite of aggressive irradiation, emphasizing the radioresistant nature of GBMs. As such, understanding the molecular mechanism of radioresistance is essential for devel...