Recently it has been shown that the proinflammatory pathway promotes effective influenza virus propagation. Based on these findings, it was suggested that blockade might be a promising method for antiviral intervention. The classical virus-induced activation of the pathway calls for proteasomal degradation of the inhibitor. For that reason, we hypothesized that inhibition of proteasomal degradation should really impair influenza A virus (IAV) replication. We chose the particular proteasome in...